717 Selective activation of CD8+ T cells by a CD8-targeted IL-2 results in enhanced anti-tumor efficacy and safety

• Published in: Journal for immunotherapy of cancer Vol. 9; no. Suppl 2; p. A746
• Main Authors: Moynihan, Kelly, Pappas, Danielle, Park, Terrence, Chen, Wei, Ni, Irene, Bessette, Paul, Chin, Mike, Schumacher, Ton, Yeung, Andy, Djuretic, Ivana
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd 01.11.2021; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Immunotherapy; Lymphocytes; Regular and Young Investigator Award Abstracts

BackgroundHigh-dose IL-2 induces complete responses in a subset of cancer patients, but severe toxicity, including vascular leak syndrome (VLS), limits its clinical potential. Insights into IL2Rα's role in the development of VLS sparked a wave of second-generation IL-2 molecules referred to as...