OP0113 GENOME-WIDE ASSOCIATION STUDY OF Ro/SSA+ AND Ro/SSA-SJÖGREN’S CASES IN THE SJÖGREN’S GENETIC NETWORK (SGENE) DEMONSTRATES DIVERGENT GENETIC ARCHITECTURE IN PATIENT SUBPHENOTYPES

• Published in: Annals of the rheumatic diseases Vol. 83; no. Suppl 1; pp. 38 - 39
• Main Authors: Rasmussen, A., Radziszewski, M., Khatri, B., Tessneer, K. L., Pontarini, E., Bombardieri, M., Rischmueller, M., Wahren-Herlenius, M., Kvarnström, M., Witte, T., Bootsma, H., Verstappen, G. M., Kroese, F. G. M., Vissink, A., Pringle, S., Tzioufas, A., Mavragani, C., Baer, A., Alarcon-Riquelme, M., Martin, J., Mariette, X., Nocturne, G., Pers, J. O., Gottenberg, J. E., Ng, W. F., Shiboski, C., Taylor, K. E., Criswell, L., Warner, B. M., Farris, A. D., James, J. A., Scofield, R. H., Guthridge, J. M., Wallace, D. J., Venuturupali, S., Brennan, M. T., Imgenberg-Kreuz, J., Ronnblom, L., Baecklund, E., Eloranta, M. L., Aqrawi, L. A., Palm, Ø., Brun, J. G., Hammenfors, D., Jonsson, M. V., Appel, S., Bucher, S. M., Forsblad-D’elia, H., Mandl, T., Eriksson, P., Nordmark, G., Lessard, C. J.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Kidlington BMJ Publishing Group Ltd and European League Against Rheumatism 01.06.2024; Elsevier B.V; Elsevier Limited
• Subjects: Autoimmune diseases; Axon guidance; Cholangitis; Chromosome 6; Epigenetics; Genetic diversity; Genetics; Genome-wide association studies; Genomes; Haplotypes; Immunosuppressive agents; Janus kinase; Kinases; Major histocompatibility complex; Morbidity; Nervous system; Ro(SSA) antigen; Scientific Abstracts; Severe combined immunodeficiency; Signal transduction; Single-nucleotide polymorphism; Sjogren's syndrome; Systemic sclerosis; Epigenetics; Genetics

Background:Sjögren’s disease (SjD) is a complex systemic autoimmune disease with substantial morbidity and 21 known genetic associations. The International Sjögren’s Genetics Network (SGENE) is a growing international collaboration focused on understanding how genetic variants influence SjD patholog...