FRI0054 Elevated 14-3-3 eta in rheumatoid arthritis and arthritogenic viral infections

• Published in: Annals of the rheumatic diseases Vol. 72; no. Suppl 3; p. A386
• Main Authors: Zhukov, O. S., Abolhosn, R. W., Popov, J. M., Naides, S. J.
• Format: Journal Article
• Language: English
• Published: Kidlington BMJ Publishing Group Ltd and European League Against Rheumatism 01.06.2013; Elsevier Limited
• ISSN: 0003-4967; 1468-2060
• DOI: 10.1136/annrheumdis-2013-eular.1181

Background The 14-3-3 proteins are ubiquitously-expressed intracellular chaperonins. Expression of the η (eta) isoform is restricted to synovial and CNS tissues.1 Extracellular 14-3-3η induces proinflammatory MAPK and NFkB cascades in THP-1 cells in vitro.2 Extracellular 14-3-3η has been proposed as...