Boosting with Omicron-matched or historical mRNA vaccines increases neutralizing antibody responses and protection against B.1.1.529 infection in mice

• Published in: bioRxiv
• Main Authors: Ying, Baoling, Scheaffer, Suzanne M, Whitener, Bradley, Liang, Chieh-Yu, Dmytrenko, Oleksandr, Mackin, Samantha, Wu, Kai, Lee, Diana, Avena, Laura E, Chong, Zhenlu, Case, James Brett, Ma, LingZhi, Kim, Thu, Sein, Caralyn, Woods, Angela, Berrueta, Daniela Montes, Carfi, Andrea, Elbashir, Sayda M, Edwards, Darin K, Thackray, Larissa B, Diamond, Michael S
• Format: Journal Article Paper
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 09.02.2022; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Antibodies; Antigens; Biotechnology; Cytokines; Infections; Microbiology; mRNA; Pandemics; Severe acute respiratory syndrome coronavirus 2; Vaccines

The B.1.1.529 Omicron variant jeopardizes vaccines designed with early pandemic spike antigens. Here, we evaluated in mice the protective activity of the Moderna mRNA-1273 vaccine against B.1.1.529 before or after boosting with preclinical mRNA-1273 or mRNA-1273.529, an Omicron-matched vaccine. Wher...