SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis

• Published in: bioRxiv
• Main Authors: Bailey, Adam L, Dmytrenko, Oleksandr, Greenberg, Lina, Bredemeyer, Andrea L, Ma, Pan, Liu, Jing, Penna, Vinay, Lai, Lulu, Winkler, Emma S, Sviben, Sanja, Brooks, Erin, Nair, Ajith P, Heck, Kent A, Rali, Aniket S, Simpson, Leo, Saririan, Mehrdad, Hobohm, Dan, Stump, W Tom, Fitzpatrick, James A, Xie, Xuping, Shi, Pei-Yong, Hinson, J Travis, Gi, Weng-Tein, Schmidt, Constanze, Leuschner, Florian, Lin, Chieh-Yu, Diamond, Michael S, Greenberg, Michael J, Lavine, Kory J
• Format: Journal Article Paper
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 05.11.2020; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: ACE2; Angiotensin; Angiotensin-converting enzyme 2; Apoptosis; Autopsy; Biotechnology; Cardiomyocytes; Cell activation; Cell death; Coronaviruses; COVID-19; Epidemiology; Heart diseases; Immunology; Infections; Laboratories; Macrophages; Muscle contraction; Myocarditis; Pandemics; Severe acute respiratory syndrome coronavirus 2; Tropism; COVID-19; Myocarditis; SARS-CoV-2; Engineered Heart Tissue; Cardiomyocyte; Macrophage

Epidemiological studies of the COVID-19 pandemic have revealed evidence of cardiac involvement and documented that myocardial injury and myocarditis are predictors of poor outcomes. Nonetheless, little is understood regarding SARS-CoV-2 tropism within the heart and whether cardiac complications resu...