Oncogene-like addiction to aneuploidy in human cancers

• Published in: bioRxiv
• Main Authors: Girish, Vishruth, Lakhani, Asad A, Scaduto, Christine M, Thompson, Sarah L, Brown, Leanne M, Hagenson, Ryan A, Sausville, Erin L, Mendelson, Brianna E, Lukow, Devon A, Yuan, Monet Lou, Kandikuppa, Pranav K, Stevens, Eric C, Lee, Sophia N, Salovska, Barbora, Li, Wenxue, Smith, Joan C, Taylor, Alison M, Martienssen, Robert A, Liu, Yansheng, Sun, Ruping, Sheltzer, Jason M
• Format: Journal Article Paper
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 10.01.2023; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Addictions; Aneuploidy; Cancer; Cancer Biology; Chromosome 1; Chromosomes; CRISPR; DNA probes; Genomes; Oncogenes; Trisomy; Tumorigenesis

Most cancers exhibit aneuploidy, but its functional significance in tumor development is controversial. Here, we describe ReDACT (Restoring Disomy in Aneuploid cells using CRISPR Targeting), a set of chromosome engineering tools that allow us to eliminate specific aneuploidies from cancer genomes. U...