Potent universal-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody

• Published in: bioRxiv
• Main Authors: Piepenbrink, Michael S, Park, Jun-Gyu, Desphande, Ashlesha, Loos, Andreas, Ye, Chengjin, Basu, Madhubanti, Sarkar, Sanghita, Chauvin, David, Woo, Jennifer, Lovalenti, Philip, Erdmann, Nathaniel B, Goepfert, Paul A, Truong, Vu L, Bowen, Richard A, Walter, Mark R, Martinez-Sobrido, Luis, Kobie, James J
• Format: Journal Article Paper
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 07.03.2022; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Coronaviruses; Immunoglobulin G; Immunology; Monoclonal antibodies; Severe acute respiratory syndrome coronavirus 2; Vaccine development; Vaccines

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) marks the third novel β-coronavirus to cause significant human mortality in the last two decades. Although vaccines are available, too few have been administered worldwide to keep the virus in check and to prevent mutations leading to immu...