Development and validation of a genomic mutation signature to predict response to PD-1 inhibitors in non-squamous NSCLC: a multicohort stud

• Published in: Journal for immunotherapy of cancer Vol. 8; no. 1
• Main Authors: Bai, Xue, Wu, De-Hua, Ma, Si-Cong, Wang, Jian, Tang, Xin-Ran, Kang, Shuai, Fu, Qiang John, Cao, Chuan-Hui, Luo, He-San, Chen, Yu-Han, Zhu, Hong-Bo, Yan, Hong-Hong, Wu, Yi-Long, Dong, Zhong-Yi
• Format: Journal Article
• Language: English
• Published: BMJ Publishing Group 30.06.2020

BackgroundGenetic variations of some driver genes in non-small cell lung cancer (NSCLC) had shown potential impact on immune microenvironment and associated with response or resistance to programmed cell death protein 1 (PD-1) blockade immunotherapy. We therefore undertook an exploratory analysis to...