SAT0315 INHIBITION OF MICROSOMAL PROSTAGLANDIN E SYNTHASE-1 (MPGES-1) BY GS-248 REDUCES PROSTAGLANDIN E2 BIOSYNTHESIS WHILE INCREASING PROSTACYCLIN IN HUMAN SUBJECTS

• Published in: Annals of the rheumatic diseases Vol. 79; no. Suppl 1; p. 1103
• Main Authors: Edenius, C., Ekström, G., Kolmert, J., Morgenstern, R., Stenberg, P., Jakobsson, P. J., Tornling, G.
• Format: Journal Article
• Language: English
• Published: BMJ Publishing Group Ltd and European League Against Rheumatism 01.06.2020
• Subjects: Scientific Abstracts

Background:Microsomal prostaglandin E synthase-1 (mPGES-1) catalyzes the formation prostaglandin (PG) E2 from cyclooxygenase derived PGH2(1, 2). Inhibition of mPGES-1 leads to reduction of pro-inflammatory PGE2, while in vessels there is a concomitant increase of vasoprotective prostacyclin (PGI2) v...