Cell type-specific assessment of cholesterol distribution in models of neurodevelopmental disorders

• Published in: bioRxiv
• Main Authors: Czernecki, Charlotte, Dixit, Shirley, Riezman, Isabelle, Innocenti, Sabrina, Pfrieger, Frank, Riezman, Howard, Scheiffele, Peter
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 17.11.2022; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Animal models; Cell culture; Cell survival; Cholesterol; Excitability; Homeostasis; Metabolism; Nervous system; Neurodevelopmental disorders; Neuronal-glial interactions; Neuroscience; Npc1 protein; Phenotypes; Synaptic transmission

Most nervous system disorders manifest through alterations in neuronal signaling based on abnormalities in neuronal excitability, synaptic transmission, and cell survival. However, such neuronal phenotypes are frequently accompanied or even caused by metabolic dysfunctions in neuronal or nonneuronal...