Prediction of elimination of intrahepatic cccDNA in hepatitis B virus-infected patients by a combination of noninvasive viral markers

• Published in: bioRxiv
• Main Authors: Iwami, Shingo, Iwamoto, Masashi, Wakita, Takaji, Watashi, Koichi, Perelson, Alan S, Tanaka, Yasuhito, Dandri, Maura, Aihara, Kazuyuki, Muramatsu, Masamichi, Iwami, Shinji, Kawakami, Eiryo, Allweiss, Lena, Tangkijvanich, Pisit, Chuaypen, Natthaya, Atsukawa, Masanori, Matsui, Takeshi, Tsukuda, Senko, Hayashi, Sanae, Kwang Su Kim, Kitagawa, Kosaku, Nishiyama, Takara, Nakamura, Naotoshi, Fujita, Yasuhisa
• Format: Paper
• Language: English; Japanese
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 04.11.2022; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Animal models; Biopsy; Cell culture; Circular DNA; Hepatitis B; Mathematical models; Microbiology; Patients; Propagation; RNA viruses

Evaluation of intrahepatic covalently closed circular DNA (cccDNA) is a key for searching an elimination of hepatitis B virus (HBV) infection. HBV RNA and HBV core-related antigen have been proposed as surrogate markers for evaluating cccDNA activity, although they do not necessarily estimate the am...