FRI0218 Shared epitope positivity is related to efficacy of abatacept in rheumatoid arthritis

• Published in: Annals of the rheumatic diseases Vol. 76; no. Suppl 2; p. 565
• Main Authors: Oryoji, K, Yoshida, K, Mizuki, S-I
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group LTD 01.06.2017
• Subjects: Antigen-presenting cells; Antigens; Epitopes; Genotypes; Medical prognosis; Patients; Phenotypes; Rheumatoid arthritis

BackgroundAbatacept, a soluble fusion protein composed of the extracellular domain of CTLA-4 molecule and the Fc portion of human IgG1, is approved therapy for RA by the mechanism of binding to CD80/86 (B7–1/B7–2) on antigen presenting cell (APC), and blocking the B7:CD28 interaction. Meanwhile, it...