Development of SARS-CoV-2 mRNA vaccines encoding spike N-terminal and receptor binding domains

• Published in: bioRxiv
• Main Authors: Stewart-Jones, Guillaume, Elbashir, Sayda M, Wu, Kai, Lee, Diana, Renzi, Isabella, Baoling Ying, Koch, Matthew, Sein, Caralyn E, Choi, Angela, Whitener, Bradley, Garcia-Dominguez, Dario, Henry, Carole, Woods, Angela, Ma, Lingzhi, Daniela Montes Berrueta, Avena, Laura E, Quinones, Julian, Falcone, Samantha, Hsiao, Chiaowen J, Scheaffer, Suzanne M, Thackray, Larissa B, White, Phil, Diamond, Michael S, Edwards, Darin K, Carfi, Andrea
• Format: Paper Journal Article
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 07.10.2022; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Biotechnology; Coronaviruses; COVID-19; Immune response; Immunology; mRNA; mRNA vaccines; Severe acute respiratory syndrome coronavirus 2; Spike protein; COVID-19; mRNA-1283; RBD; vaccines; challenge; mice; immunogenicity; viral variants; NTD

With the success of mRNA vaccines against coronavirus disease 2019 (COVID-19), strategies can now focus on improving vaccine potency, breadth, and stability. We present the design and preclinical evaluation of domain-based mRNA vaccines encoding the wild-type spike-protein receptor-binding (RBD) and...