Matrix Metalloprotease-3 and -9 Proteolyze Insulin-Like Growth Factor-Binding Protein-11

• Published in: Biology of reproduction Vol. 71; no. 2; pp. 438 - 443
• Main Authors: Coppock, Hedley A, White, Anne, Aplin, John D, Westwood, Melissa
• Format: Journal Article
• Language: English
• Published: 01.08.2004
• Subjects: Contents; decidua; growth factors; placenta; trophoblast

Growth in utero depends on adequate development and function of the fetal/maternal interface. During pregnancy, the insulin-like growth factors (IGFs), which are known to be critically involved in placental development, are controlled by a binding protein—IGFBP-1—produced by maternal decidualized en...