Differential cell signaling testing for cell-cell communication inference from single-cell data by dominoSignal

• Published in: bioRxiv
• Main Authors: Mitchell, Jacob T, Stapleton, Orian, Krishnan, Kavita, Nagaraj, Sushma, Lvovs, Dmitrijs, Cherry, Christopher, Poissonnier, Amanda, Horton, Wes, Adey, Andrew, Rao, Varun, Huff, Amanda, Zimmerman, Jacquelyn W, Kagohara, Luciane T, Zaidi, Neeha, Coussens, Lisa M, Jaffee, Elizabeth M, Elisseeff, Jeniffer H, Fertig, Elana J
• Format: Journal Article Paper
• Language: English
• Published: United States Cold Spring Harbor Laboratory 03.05.2025
• Edition: 1.1
• Subjects: Bioinformatics

Algorithms for ligand-receptor network inference have emerged as commonly used tools to estimate cell-cell communication from reference single-cell data. Many studies employ these algorithms to compare signaling between conditions and lack methods to statistically identify signals that are significa...