Immune memory shapes human polyclonal antibody responses to H2N2 vaccination

• Published in: bioRxiv
• Main Authors: Yang, Yuhe R, Han, Julianna, Perrett, Hailee R, Richey, Sara T, Jackson, Abigail M, Rodriguez, Alesandra J, Gillespie, Rebecca A, O'Connell, Sarah, Raab, Julie E, Cominsky, Lauren Y, Chopde, Ankita, Kanekiyo, Masaru, Houser, Katherine V, Chen, Grace L, McDermott, Adrian B, Andrews, Sarah F, Ward, Andrew B
• Format: Journal Article Paper
• Language: English
• Published: United States Cold Spring Harbor Laboratory 24.08.2023
• Edition: 1.1
• Subjects: Immunology; influenza; neutralizing antibody; structure-based vaccine design; cryoEM; hemagglutinin

Influenza A virus subtype H2N2, which caused the 1957 influenza pandemic, remains a global threat. A recent phase I clinical trial investigating a ferritin nanoparticle displaying H2 hemagglutinin in H2-naïve and H2-exposed adults. Therefore, we could perform comprehensive structural and biochemical...