Hypersensitivity of the vimentin cytoskeleton to net-charge states and Coulomb repulsion

• Published in: bioRxiv
• Main Authors: Unger, Bret A, Wu, Chun Ying, Choi, Alexander A, He, Changdong, Xu, Ke
• Format: Journal Article Paper
• Language: English
• Published: United States Cold Spring Harbor Laboratory 11.07.2024
• Edition: 1.1
• Subjects: Biophysics

As with most intermediate filament systems, the hierarchical self-assembly of vimentin into nonpolar filaments requires no nucleators or energy input. Utilizing a set of live-cell, single-molecule, and super-resolution microscopy tools, here we show that in mammalian cells, the assembly and disassem...