Serine palmitoyltransferase-mediated de novo sphingolipid biosynthesis is required for normal insulin production and glucose tolerance

• Published in: bioRxiv
• Main Authors: Amouyal, Chloé, Chen, Shiou Ping, Denom, Jessica, Raho, Ilyès, Kassis, Nadim, Diedisheim, Marc, Mifsud, François, Lallement, Justine, Georgiadou, Eleni, Ibberson, Mark, Croyal, Mikael, Jiang, Xian C, Cruciani-Guglielmacci, Céline, Le Stunff, Hervé, Rutter, Guy A, Magnan, Christophe
• Format: Journal Article Paper
• Language: English
• Published: United States Cold Spring Harbor Laboratory 17.05.2025
• Edition: 1.1
• Subjects: Physiology; sphingomyelin; diabetes; Beta cell mass; ceramides; ceramides, sphingomyelin
• ISSN: 2692-8205; 2692-8205
• DOI: 10.1101/2025.05.14.653935

The importance for normal insulin secretion of ceramide synthesis is unclear. ceramide synthesis requires serine palmitoyl transferase, SPT2, encoded by . We generated β-cell-selective null mice by crossing animals with alleles to mice expressing recombinase from the locus. Metabolic phenotyping, tr...