Parkinson's disease-associated alterations in DNA methylation and hydroxymethylation in human brain

• Published in: bioRxiv
• Main Authors: Choza, Juliana I, Virani, Mahek, Kuhn, Nathan C, Adams, Marie, Kochmanski, Joseph, Bernstein, Alison I
• Format: Journal Article Paper
• Language: English
• Published: United States Cold Spring Harbor Laboratory 02.02.2025
• Edition: 1.3
• Subjects: Neuroscience

Epigenetic mechanisms are mediators of interactions between aging, genetics, and environmental factors in sporadic Parkinson's disease (PD). Multiple studies have explored the DNA modifications in PD, but few focus on 5-hydroxymethylcytosine (5-hmC), which is important in the central nervous sy...