578 Anti-PD-1 therapy alters the generation and durability of de novo responses to vaccination in humans

• Published in: Journal for immunotherapy of cancer Vol. 11; no. Suppl 1; p. A657
• Main Authors: Burke, Kelly P, Chicz, Taras M, Baginska, Joanna, Huezo, Julia, Holovatska, Marta, Manos, Michael, Yoo, Duck Kyun, Keerti, Fnu, Bi, Caihong, McNamara, Ryan, Wesemann, Duane, Stephen Hodi, F, Buchbinder, Elizabeth I, Sharpe, Arlene
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd 01.11.2023; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Antibodies; Antigens; Cancer; Immune response; Immunoglobulins; Immunotherapy; Influenza; Regular and Young Investigator Award Abstracts; Severe acute respiratory syndrome coronavirus 2; Tetanus; Trends; Vaccines

BackgroundAlthough anti-PD-1 expands pre-existing tumor-specific T cell responses, preclinical models of infection and vaccination suggest that early PD-1 pathway blockade may preferentially expand effector cells at the expense of memory cell or immunoglobulin generation. This has important ramifica...