CCR2-dependent monocyte-derived cells restrict SARS-CoV-2 infection

• Published in: bioRxiv
• Main Authors: Vanderheiden, Abigail, Thomas, Jeronay, Soung, Allison L, Davis-Gardner, Meredith E, Floyd, Katharine, Jin, Fengzhi, Cowan, David A, Pellegrini, Kathryn, Creanga, Adrian, Pegu, Amarendra, Derrien-Colemyn, Alexandrine, Shi, Pei-Yong, Grakoui, Arash, Klein, Robyn S, Bosinger, Steven E, Kohlmeier, Jacob E, Menachery, Vineet D, Suthar, Mehul S
• Format: Journal Article Paper
• Language: English
• Published: United States Cold Spring Harbor Laboratory 04.05.2021
• Edition: 1.1
• Subjects: Immunology

SARS-CoV-2 has caused a historic pandemic of respiratory disease (COVID-19) and current evidence suggests severe disease is associated with dysregulated immunity within the respiratory tract. However, the innate immune mechanisms that mediate protection during COVID-19 are not well defined. Here we...