1346 mTFF2-MSA (mTNX-1700) suppresses tumor growth in an Anti-PD-1 treated Pan02 syngeneic pancreatic cancer model by targeting MDSCs in C57BL/6 Mice

• Published in: Journal for immunotherapy of cancer Vol. 11; no. Suppl 1; p. A1500
• Main Authors: Daugherty, Bruce L, Zhao, Grace, Zang, Mingfa, Qian, Jin, Wang, Timothy C, Lederman, Seth
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd 01.11.2023; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Colorectal cancer; Flow cytometry; Immunotherapy; Lymphatic system; Pancreatic cancer; Peptides; Regular and Young Investigator Award Abstracts

BackgroundMyeloid-derived suppressor cells (MDSCs) in the tumor microenvironment are potential therapeutic targets in immune checkpoint cancer therapy, particularly for cancers that are unresponsive to anti-PD-1 therapy. It has previously been demonstrated that trefoil factor family 2 (TFF2), a secr...