481 A CXCR4 partial agonist TFF2-MSA sensitized advanced gastric cancer to PD-1 blockade by systematically reducing PMN-MDSC accumulation, immunosuppression, and generation in bone marrow

• Published in: Journal for immunotherapy of cancer Vol. 11; no. Suppl 1; p. A540
• Main Authors: Qian, Jin, Ryeom, Sandra, Daugherty, Bruce L, Lederman, Seth, Wang, Timothy C
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd 01.11.2023; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Agonists; Bone marrow; Flow cytometry; Gastric cancer; Histamine; Immunotherapy; Lung cancer; Metastasis; Neutrophils; Regular and Young Investigator Award Abstracts; Stem cells; Tumors

BackgroundPolymorphonuclear myeloid-derived suppressor cell (PMN-MDSC) is pathologically activated immature neutrophil that exerts immunosuppressive functions. PMN-MDSC is short-lived and constantly replenished through bone marrow (BM) myelopoiesis. Within the BM, histidine decarboxylase (HDC) expre...