740 Biomarkers diverging between tumor mutation burden and microsatellite instability

• Published in: Journal for immunotherapy of cancer Vol. 8; no. Suppl 3; pp. A786 - A787
• Main Authors: Ding, Jason, Patel, Nihir
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group LTD 01.11.2020; BMJ Publishing Group
• Subjects: Biomarkers; Cancer; Colorectal cancer; DNA polymerase; DNA repair; Endometrial cancer; Gene expression; Immunotherapy; Mutation

BackgroundDNA repair is a critical process to maintain DNA integrity. It is conducted by distinct pathways of genes, many of whose alterations are thought to result in genomic instability and hypermutability, ultimately contributing to tumorigenesis. Tumor Mutation Burden (TMB) and Microsatellite In...