396 NT-I7, a long-acting interleukin-7, promotes expansion of CD8 T cells and NK cells and immune activation in patients with newly diagnosed high-grade gliomas after chemoradiation

• Published in: Journal for immunotherapy of cancer Vol. 9; no. Suppl 2; p. A428
• Main Authors: Zhou, Alice, Rettig, Michael, Foltz, Jennifer, Luo, Jingqin, Butt, Omar, Avvaru, Chai, Katumba, Ruth, Kim, Albert, Dunn, Gavin, Abraham, Christopher, Yang, Se Hwan, Fan, Jean, Lee, Byung Ha, Le, NgocDiep, Ansstas, George, Johanns, Tanner, Huang, Jiayi, Chheda, Milan, Fehniger, Todd, Campian, Jian
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd 01.11.2021; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Brain cancer; Cytokines; Cytotoxicity; Flow cytometry; Glioma; Immunotherapy; Radiation; Regular and Young Investigator Award Abstracts; Tumor necrosis factor-TNF

BackgroundLymphopenia is common after chemoradiation for treatment of high-grade gliomas (HGG) and is associated with reduced survival.1 Interleukin-7 (IL-7) promotes T-cell maturation and proliferation and is inappropriately low in lymphopenic patients with HGG.2 We previously demonstrated that fir...