891 S-531011, a novel anti-human CCR8 antibody: antibody screening and evaluation of biological profiles

• Published in: Journal for immunotherapy of cancer Vol. 9; no. Suppl 2; p. A934
• Main Authors: Yoshikawa, Mai, Nagira, Yoji, Nagira, Morio, Yoshida, Tetsuya, Yoshida, Shinpei, Soh, Tetsuyoshi, Wada, Hisashi, Ohkura, Naganari, Takahashi, Tatsuya
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd 01.11.2021; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Antibodies; Immunization; Immunotherapy; Regular and Young Investigator Award Abstracts

BackgroundRegulatory T cells (Tregs) are involved in tumor progression and inhibition of anti-tumor immune responses by promotion of immunological tolerance in the tumor microenvironment. On the other hand, Treg cells in peripheral blood are also essential role in preventing autoimmunity and uncontr...