O011 Why joint location matters in the pathogenesis of rheumatoid arthritis

• Published in: Annals of the rheumatic diseases Vol. 77; no. Suppl 1; pp. A5 - A6
• Main Authors: Frank Bertoncelj, M, Karouzakis, E, Masterson, T, Kolling, C, Distler, O, Ospelt, C
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Limited 01.03.2018
• Subjects: Arthralgia; Cell cycle; Chemotaxis; Cycle protein; Deoxyribonucleic acid; DNA; DNA methylation; Embryogenesis; Enhancers; Fibroblasts; Gene expression; Hand; Homeobox; Hyperplasia; Inflammation; Joint diseases; Knee; Osteoarthritis; Paraffin; Promoters; Protein interaction; Proteins; Rheumatoid arthritis; Shoulder; Stromal cells; Synovitis

IntroductionInflammatory arthritis, such as rheumatoid arthritis (RA) and spondyloarthropaties, follows a characteristic anatomical pattern of joint involvement. We suggest that the local cell types, systemic triggers and site-specific exogenous factors that activate these local cells synergisticall...