POS0089 A DIAGNOSTIC PERFORMANCE STUDY ON RAMAN SPECTROSCOPY INTEGRATED WITH POLARIZED LIGHT MICROSCOPY FOR THE IDENTIFICATION OF MONOSODIUM URATE IN GOUT

• Published in: Annals of the rheumatic diseases Vol. 82; no. Suppl 1; pp. 257 - 258
• Main Authors: Niessink, T., Giesen, T., Comarniceanu, A., Efde, M., Janssen, M., Otto, C., Jansen, T.
• Format: Journal Article
• Language: English
• Published: Kidlington BMJ Publishing Group Ltd and European League Against Rheumatism 01.06.2023; Elsevier Limited
• Subjects: Arthritis; Classification; Crystal Arthritis; Crystals; Diagnosis; Diagnostic Tests; Gout; Light microscopy; Microscopy; Polarized light; Raman spectroscopy; Reproducibility; Rheumatology; Scientific Abstracts; Spectrum analysis; Stockholders; Synovial fluid; Uric acid

BackgroundThe diagnosis in gout and other crystallopathies is commonly based on polarized light microscopy (PLM) of synovial fluid aspirates. This technique is flawed, however, due to subjectivity, limited reproducibility, and oversensitivity due to artifacts [1]. There is a need for innovative meth...