THU0179 Mir-382–5p targeting il-33 gene as biomarker to predict subclinical atherosclerosis progression in patients with early rheumatoid arthritis

• Published in: Annals of the rheumatic diseases Vol. 77; no. Suppl 2; p. 308
• Main Authors: Cheng, T.H., Shang, Q., Li, E. K. M., Li, M., Mak, W.Y., Kwok, K.Y., Yim, I.C.W., Wong, P.C.H., Lao, V.W.N., Pang, S.H.T., Kun, E.W.L., Tam, L.S.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Limited 01.06.2018
• Subjects: Arteriosclerosis; Atherosclerosis; Biomarkers; Cardiovascular diseases; Chromosome 5; Gene expression; Health risk assessment; Hip; Interleukin 1; Low density lipoprotein; Metabolic disorders; miRNA; Pain; Patients; Rheumatoid arthritis; Risk assessment; Ultrasound

BackgroundPatients with rheumatoid arthritis(RA) had increased risk of cardiovascular disease(CVD). IL-33, a member of the IL-1 family, plays an important role in the pathogenesis of RA and development of CVD. Yet, plasma IL-33 level was not detectable in most subjects which limits it’s utility as a...