SAT0043 Il-33/st2-mediated inflammation in endothelial cell is directly aggravated by il-6 during lupus nephritis

• Published in: Annals of the rheumatic diseases Vol. 77; no. Suppl 2; pp. 886 - 887
• Main Authors: Yu, S.L., Huo, Y.B., Huang, C.H., Tao, Y., Huang, W.H., Wong, C.K., Tam, L.S., Qiu, H.N., Chen, R.L., Zhong, L.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Limited 01.06.2018
• Subjects: 4',6-Diamidino-2-phenylindole; Atrophy; Cancer; CD123 antigen; CD14 antigen; CD16 antigen; CD34 antigen; Dendritic cells; Endothelial cells; Endothelium; External stimuli; Immune response; Immune system; Immunofluorescence; Inflammation; Innate immunity; Interleukin 12; Interleukin 13; Interleukin 4; Interleukin 5; Interleukin 6; Intracellular; Kidney cancer; Localization; Lupus; Lupus nephritis; Nephritis; Nuclei; Pathogenesis; Systemic lupus erythematosus

Background”Alarmins” are prototypic endogenous pro-inflammatory factors as they are released from necotic cells and provoke local damage or systemic inflammation. Evidences are accumulating to support the inclusion of ”Alarmins” as targets of autoreactivity as well as inducers in the pathogenesis of...