AB0097 Individual functions of the histone-acetyltransferases cbp and p300 in rheumatoid arthritis synovial fibroblasts

• Published in: Annals of the rheumatic diseases Vol. 77; no. Suppl 2; p. 1244
• Main Authors: Lee, G., Kolling, C., Distler, O., Ospelt, C., Klein, K.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Limited 01.06.2018
• Subjects: Acetylation; Antisense RNA; Cyclic AMP response element-binding protein; Drug development; Enhancers; Event-related potentials; Fibroblasts; Gene expression; Hand; Interleukin 6; Interleukin 8; Lysine; Protein expression; Proteins; Rheumatoid arthritis; Transfection; Tumor necrosis factor-α; Western blotting

BackgroundThe close homologues cAMP-response element binding protein (CREB) binding protein (CBP) and p300 are writers of H3K27 histone acetylation marks found in active enhancers. In addition, their bromodomains are readers of acetylated lysine residues on histone tails and are subject of drug deve...