Relationship Between kdr Mutation and Resistance to Pyrethroid and DDT Insecticides in Natural Populations of Anopheles gambiae

• Published in: Journal of medical entomology Vol. 45; no. 2; pp. 260 - 266
• Main Authors: Reimer, L, Fondjo, E, Patchoke, S, Diallo, B, Lee, Y, Ng, A, Ndjemai, H.M, Atangana, J, Traore, S.F, Lanzaro, G
• Format: Journal Article
• Language: English
• Published: England 01.03.2008
• Subjects: Alleles; amino acid substitution; Animals; Anopheles - genetics; Anopheles gambiae; Cameroon; DDT; DDT (pesticide); Gene Frequency; genetic polymorphism; genetic resistance; genotype; insecticide resistance; Insecticide Resistance - genetics; Insecticides; knockdown resistance; M molecular form; mutation; population genetics; Pyrethrins; pyrethroid insecticides; resistance alleles; S molecular forms; sodium channels; Sodium Channels - genetics; Cameroon

The spread of insecticide resistance genes in Anopheles gambiae Giles sensu stricto threatens to compromise vector-based malaria control programs. Two mutations at the same locus in the voltage-gated sodium channel gene are known to confer knockdown resistance (kdr) to pyrethroids and DDT. Kdr-e inv...