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[...]the authors used this model to identify potential colon cancer driver genes, using gene editing and deep sequencing at the point of earliest invasion and yielded a panel of genes that were mutated. In this study, Caminero and colleagues used germfree C57BL/6 mice to study gluten metabolism capa...

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Bibliographic Details
Published inGut Vol. 65; no. 11; pp. 1916 - 1917
Main Author McLean, Mairi H
Format Journal Article
LanguageEnglish
Published London BMJ Publishing Group LTD 01.11.2016
Subjects
Acids
Bacteria
Cancer therapies
Celiac disease
Disease
Drug dosages
Gastroenterology
Gluten
Hepatology
Ligands
Liver cancer
Mutation
Tumors
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Summary:[...]the authors used this model to identify potential colon cancer driver genes, using gene editing and deep sequencing at the point of earliest invasion and yielded a panel of genes that were mutated. In this study, Caminero and colleagues used germfree C57BL/6 mice to study gluten metabolism capabilities of opportunistic pathogens associated with CD, including Pseudomonas aeruginosa, and a number of commensal duodenal bacteria. Published Online First. doi: 10.1002/hep.28710 Immunomodulatory antibodies directed against the T cell receptor programmed cell death protein-1 (PD-1) have drastically changed the prognosis of some tumour entities and are currently undergoing clinical investigation for the treatment of hepatocellular cancer (HCC).
ISSN:0017-5749
1468-3288
DOI:10.1136/gutjnl-2016-312934