Endogenous controllability of closed-loop brain-machine interfaces for pain

• Published in: bioRxiv
• Main Authors: Zhang, Suyi, Yoshida, Wako, Mano, Hiroaki, Yanagisawa, Takufumi, Shibata, Kazuhisa, Kawato, Mitsuo, Seymour, Ben
• Format: Paper
• Language: English; Japanese
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 16.07.2018; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Brain mapping; Computational neuroscience; Cortex (cingulate); Feedback; Functional magnetic resonance imaging; Interfaces; Learning algorithms; Neural coding; Neuroscience; Pain; Pain perception; Prefrontal cortex; Somatosensory cortex

The ultimate aim of closed-loop brain-machine systems for pain is to directly titrate the ongoing level of an intervention to pain-related neural activity. However pain is highly susceptible to endogenous modulation, raising the possibility that active or passive changes in neural activity provoked...