Semenogelin II Gene Is Replaced by a Truncated LINE1 Repeat in the Cotton-Top Tamarin1
The human seminal vesicles secrete two proteins, semenogelin I and semenogelin II, at very high concentrations. It has previously been shown that the cotton-top tamarin (Sanguinus oedipus), a New World monkey, is lacking the semenogelin II gene. We have now determined the nucleotide sequence of DNA...
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Published in | Biology of reproduction Vol. 65; no. 2; pp. 420 - 425 |
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Main Authors | , |
Format | Journal Article |
Language | English |
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01.08.2001
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Abstract | The human seminal vesicles secrete two proteins, semenogelin I and semenogelin II, at very high concentrations. It has previously been shown that the cotton-top tamarin (Sanguinus oedipus), a New World monkey, is lacking the semenogelin II gene. We have now determined the nucleotide sequence of DNA located 5–13 kilobases (kb) downstream of the tamarin semenogelin I gene—a region that in man is occupied by the semenogelin II gene. Two regions with homology to the human semenogelin II gene were identified in the tamarin DNA. The first region, of 3.5 kb, is homologous to DNA upstream of the human gene, and the second region, of 0.6 kb, is mainly derived from the second intron. Between these regions, equivalent to 594 base pairs (bp) upstream of the transcription initiation site to 12 bp downstream of the stop codon in the human semenogelin II gene, the cotton-top tamarin DNA carries a truncated LINE1 repeat. In another set of experiments, the tamarin DNA hybridizing to the mouse semenoclotin gene was investigated. It was concluded that hybridization is with the second intron of the semenoclotin gene, but very likely, the material does not represent a cotton-top tamarin semenoclotin gene. Thus, a mammalian ancestor probably carried a single gene that in the rodent lineage developed into the semenoclotin gene and in the primate lineage into a progenitor of the semenogelin genes. |
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AbstractList | The human seminal vesicles secrete two proteins, semenogelin I and semenogelin II, at very high concentrations. It has previously been shown that the cotton-top tamarin (Sanguinus oedipus), a New World monkey, is lacking the semenogelin II gene. We have now determined the nucleotide sequence of DNA located 5–13 kilobases (kb) downstream of the tamarin semenogelin I gene—a region that in man is occupied by the semenogelin II gene. Two regions with homology to the human semenogelin II gene were identified in the tamarin DNA. The first region, of 3.5 kb, is homologous to DNA upstream of the human gene, and the second region, of 0.6 kb, is mainly derived from the second intron. Between these regions, equivalent to 594 base pairs (bp) upstream of the transcription initiation site to 12 bp downstream of the stop codon in the human semenogelin II gene, the cotton-top tamarin DNA carries a truncated LINE1 repeat. In another set of experiments, the tamarin DNA hybridizing to the mouse semenoclotin gene was investigated. It was concluded that hybridization is with the second intron of the semenoclotin gene, but very likely, the material does not represent a cotton-top tamarin semenoclotin gene. Thus, a mammalian ancestor probably carried a single gene that in the rodent lineage developed into the semenoclotin gene and in the primate lineage into a progenitor of the semenogelin genes. |
Author | Lundwall, Åke M. Olsson, A. Yvonne |
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CitedBy_id | crossref_primary_10_1095_biolreprod_106_057661 crossref_primary_10_1093_molbev_msn237 crossref_primary_10_1016_j_theriogenology_2007_10_016 crossref_primary_10_1016_j_gene_2004_09_020 crossref_primary_10_1101_gr_6004607 crossref_primary_10_1093_molbev_msn182 |
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SubjectTerms | Contents gene regulation male reproductive tract seminal vesicles sperm motility and transport |
Title | Semenogelin II Gene Is Replaced by a Truncated LINE1 Repeat in the Cotton-Top Tamarin1 |
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