P119 T-bet+ B cells can serve as prognostic and therapeutic tools for human systemic lupus erythematosus

• Published in: Lupus science & medicine Vol. 11; no. Suppl 1; pp. A125 - A126
• Main Authors: Sachinidis, Athanasios, Trachana, Maria, Taparkou, Anna, Keisaris, Sofoklis, Gavriilidis, George, Verginis, Panayotis, Adamichou, Christina, Boumpas, Dimitrios, Garyfallos, Alexandros
• Format: Journal Article
• Language: English
• Published: London Lupus Foundation of America 01.03.2024; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Lupus; Monoclonal antibodies; Poster Presentations; Transcription factors

ObjectiveThis study aims to clarify whether T-bet+ B cells, as well as the sub-populations of age-associated B cells/ABCs (CD19+CD21-CD11c+T-bet+) and double-negative B cells/DN (CD19+IgD-CD27-CXCR5-T-bet+), serve as prognostic and/or therapeutic tools for systemic lupus erythematosus (SLE) in human...