Direct Relationship between Protein Expression and Progeny Yield of Herpes Simplex Virus 1 Unveils a Rate-limiting Step for Virus Production

• Published in: bioRxiv
• Main Authors: Nobe, Moeka, Maruzuru, Yuhei, Takeshima, Kosuke, Maeda, Fumio, Kusano, Hideo, Yoshimura, Raiki, Nishiyama, Takara, Park, Hyeongki, Kozaki, Yoshitaka, Iwami, Shingo, Koyanagi, Naoto, Kato, Akihisa, Natsume, Tohru, Adachi, Shungo, Kawaguchi, Yasushi
• Format: Paper
• Language: Japanese
• Published: Cold Spring Harbor Laboratory 08.06.2023
• Edition: 1.2
• Subjects: Microbiology

Although viral protein expression and progeny virus production were independently shown to be highly heterogenous in individual cells, their direct relationship, analyzed by considering their heterogeneities, has not been investigated to date. This study established a system to fractionate cells inf...