Two doses of mRNA vaccine elicit cross-neutralizing memory B-cells against SARS-CoV-2 Omicron variant

• Published in: bioRxiv
• Main Authors: Kotaki, Ryutaro, Adachi, Yu, Moriyama, Saya, Onodera, Taishi, Fukushi, Shuetsu, Nagakura, Takaki, Tonouchi, Keisuke, Terahara, Kazutaka, Sun, Lin, Takano, Tomohiro, Nishiyama, Ayae, Shinkai, Masaharu, Oba, Kunihiro, Nakamura-Uchiyama, Fukumi, Shimizu, Hidefumi, Suzuki, Tadaki, Matsumura, Takayuki, Isogawa, Masanori, Takahashi, Yoshimasa
• Format: Paper
• Language: Japanese
• Published: Cold Spring Harbor Laboratory 26.12.2021
• Edition: 1.1
• Subjects: Immunology

SARS-CoV-2 Beta and Omicron variants have multiple mutations in the receptor-binding domain (RBD) allowing antibody evasion. Despite the resistance to circulating antibodies in those who received two doses of mRNA vaccine, the third dose prominently recalls cross-neutralizing antibodies with expande...