Naturally mutated spike proteins of SARS-CoV-2 variants show differential levels of cell entry

• Published in: bioRxiv
• Main Authors: Ozono, Seiya, Zhang, Yanzhao, Ode, Hirotaka, Tan, Toong Seng, Imai, Kazuo, Miyoshi, Kazuyasu, Kishigami, Satoshi, Ueno, Takamasa, Iwatani, Yasumasa, Suzuki, Tadaki, Tokunaga, Kenzo
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 26.06.2020; Cold Spring Harbor Laboratory
• Edition: 1.2
• Subjects: ACE2; Angiotensin; Angiotensin-converting enzyme 2; Antisera; Coronaviruses; COVID-19; Disease transmission; Infectivity; Microbiology; Mutants; Mutation; Pandemics; Peptidyl-dipeptidase A; Serine; Severe acute respiratory syndrome coronavirus 2

The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is steadily mutating during continuous transmission among humans. Such mutations can occur in the spike (S) protein that binds to the angiotensin-converting enzyme-2...