Durability of immune responses to the BNT162b2 mRNA vaccine

• Published in: bioRxiv
• Main Authors: Suthar, Mehul, Arunachalam, Prabhu S, Hu, Mengyun, Reis, Noah, Trisal, Meera, Raeber, Olivia, Chinthrajah, Sharon, Davis-Gardner, Meredith E, Manning, Kelly, Mudvari, Prakriti, Godbole, Sucheta, Boritz, Eli, Henry, Amy R, Douek, Daniel, Nadeau, Kari, Kawaoka, Yoshihiro, Zarnitsyna, Veronika I, Bali Pulendran, Halfmann, Peter
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 30.09.2021; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Adaptive immunity; Antibodies; Immunology; Lymphocytes; Lymphocytes T; mRNA; mRNA vaccines; Severe acute respiratory syndrome coronavirus 2; Vaccine efficacy; Vaccines

The development of the highly efficacious mRNA vaccines in less than a year since the emergence of SARS-CoV-2 represents a landmark in vaccinology. However, reports of waning vaccine efficacy, coupled with the emergence of variants of concern that are resistant to antibody neutralization, have raise...