FRI0030 Jak2/stat3 is a major pathway of leptin-induced interleukin-6 production by rheumatoid synovial fibroblasts

• Published in: Annals of the rheumatic diseases Vol. 72; no. Suppl 3; p. A378
• Main Authors: Muraoka, S., Kusunoki, N., Shikano, K., Kaburaki, M., Kitahara, K., Tanaka, N., Kaneko, K., Yamamoto, T., Kusunoki, Y., Takagi, K., Hasunuma, T., Endo, H., Kawai, S.
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and European League Against Rheumatism 01.06.2013; BMJ Publishing Group LTD

Background Since proinflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6, play major pathophysiological roles in rheumatoid arthritis (RA), their inhibitors have recently been developed as potent biological anti-rheumatic drugs. However, they are not curat...