FRI0046 Characterization of nitrotyrosine as a clinical biomarker for arthritis and joint injury

• Published in: Annals of the rheumatic diseases Vol. 71; no. Suppl 3; pp. 324 - 325
• Main Authors: Misko, T.P., Radabaugh, M.R., Highkin, M., Abrams, M., Listello, J., Friese, O., Gallavan, R., Bramson, C., Hellio le Graverand-Gastineau, M.P., Lohmander, L.S., Roman, D.
• Format: Journal Article
• Language: English
• Published: Kidlington BMJ Publishing Group Ltd and European League Against Rheumatism 01.06.2013; Elsevier Limited

Background Increased nitric oxide synthase (NOS) activity has been linked to joint injury and is associated with increased chondrocyte apoptosis, increased matrix metalloproteinase (MMP) activity, and decreased extracellular matrix synthesis. Osteoarthritis (OA) and rheumatoid arthritis (RA) show in...