Rational Design of TDP-43 Derived α-Helical Peptide Inhibitors: an In-Silico Strategy to Prevent TDP-43 Aggregation in Neurodegenerative Disorders

• Published in: bioRxiv
• Main Authors: Salaikumaran, Muthu Raj, Gopal, Pallavi P
• Format: Journal Article Paper
• Language: English
• Published: United States Cold Spring Harbor Laboratory 31.10.2023
• Edition: 1.1
• Subjects: Neuroscience; aggregation; neurodegenerative disease; Helical Propensity Peptide; TDP-43

TDP-43, an essential RNA/DNA-binding protein, is central to the pathology of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Pathological mislocalization and aggregation of TDP-43 disrupts RNA splicing, mRNA stability, and mRNA transport, thereby impairi...