HTLV-1 Tax induces PINK1-Parkin-dependent mitophagy to mitigate activation of the cGAS-STING pathway

Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma (ATLL) and the neuroinflammatory disease, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The HTLV-1 Tax regulatory protein plays a critical role in HTLV-1 persistence and pathog...

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Bibliographic Details
Published inbioRxiv
Main Authors Mohanty, Suchitra, Suklabaidya, Sujit, Mnatsakanyan, Nelli, Jacobson, Steven, Harhaj, Edward W
Format Journal Article Paper
LanguageEnglish
Published United States Cold Spring Harbor Laboratory 15.03.2025
Edition1.1
Subjects
Microbiology
mitophagy
mitochondria
cGAS
STING
HTLV-1
Tax
NDP52
NEMO
Parkin
Online AccessGet full text
ISSN2692-8205
2692-8205
DOI10.1101/2025.03.15.643451

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