Structural and functional characterization of integrin α5-targeting antibodies for anti-angiogenic therapy

• Published in: bioRxiv
• Main Authors: Nguyen, Adam, Heim, Joel B, Cordara, Gabriele, Chan, Matthew C, Johannesen, Hedda, Charlesworth, Cristine, Li, Ming, Azumaya, Caleigh M, Madden, Benjamin, Krengel, Ute, Meves, Alexander, Campbell, Melody G
• Format: Journal Article Paper
• Language: English
• Published: United States Cold Spring Harbor Laboratory 09.01.2025
• Edition: 1.1
• Subjects: Biochemistry

Integrins are a large family of heterodimeric receptors important for cell adhesion and signaling. Integrin α5β1, also known as the fibronectin receptor, is a key mediator of angiogenesis and its dysregulation is associated with tumor proliferation, progression, and metastasis. Despite numerous effo...