The Death of Sertoli Cells and the Capacity to Phagocytize Elongated Spermatids During Testicular Regression due to Short Photoperiod in Syrian Hamster (Mesocricetus auratus)1
In the Syrian hamster (Mesocricetus auratus), an animal that displays testicular regression due to short photoperiod, germ cells are removed by apoptosis during this process and the apoptotic remains are phagocytized by Sertoli cells. The aim of this work was to investigate morphologically whether t...
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Published in | Biology of reproduction Vol. 90; no. 5 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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01.05.2014
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Abstract | In the Syrian hamster (Mesocricetus auratus), an animal that displays testicular regression due to short photoperiod, germ cells are removed by apoptosis during this process and the apoptotic remains are phagocytized by Sertoli cells. The aim of this work was to investigate morphologically whether the testicular regression process due to short photoperiod leads to the apoptosis of Sertoli cells, and whether, during testicular regression, the elongated spermatids are eliminated through phagocytosis by Sertoli cells. To this end, we studied testis sections during testicular regression in Syrian hamster subjected to short photoperiod by means of several morphological techniques using conventional light microscopy (hematoxylin and eosin [H&E], semi-thin section vimentin, immunohistochemistry, SBA lectin, and TUNEL staining), fluorescence microscopy, and transmission electron microscopy (TEM). H&E and semi-thin sections identified Sertoli cells with a degenerated morphology. Greater portion of Sertoli cells that were positive for TUNEL staining were observed especially during the mild regression (MR) and strong regression (SR) phases. In addition, TEM identified the characteristic apoptotic changes in the nucleus and cytoplasm of Sertoli cells. Moreover, during testicular regression and using light microscopy, some elongated spermatids were seen in basal position next to the Sertoli cell nucleus. This Sertoli phagocytic activity was higher in MR and SR phases. TEM confirmed this to be the result of the phagocytic activity of Sertoli cells. In conclusion, during testicular regression in Syrian hamster due to short photoperiod, when germ cells are known to be lost through apoptosis, there is morphological evidences that Sertoli cells are also lost through apoptosis, while some elongated spermatids are phagocytized and eliminated by the Sertoli cells. |
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AbstractList | In the Syrian hamster (Mesocricetus auratus), an animal that displays testicular regression due to short photoperiod, germ cells are removed by apoptosis during this process and the apoptotic remains are phagocytized by Sertoli cells. The aim of this work was to investigate morphologically whether the testicular regression process due to short photoperiod leads to the apoptosis of Sertoli cells, and whether, during testicular regression, the elongated spermatids are eliminated through phagocytosis by Sertoli cells. To this end, we studied testis sections during testicular regression in Syrian hamster subjected to short photoperiod by means of several morphological techniques using conventional light microscopy (hematoxylin and eosin [H&E], semi-thin section vimentin, immunohistochemistry, SBA lectin, and TUNEL staining), fluorescence microscopy, and transmission electron microscopy (TEM). H&E and semi-thin sections identified Sertoli cells with a degenerated morphology. Greater portion of Sertoli cells that were positive for TUNEL staining were observed especially during the mild regression (MR) and strong regression (SR) phases. In addition, TEM identified the characteristic apoptotic changes in the nucleus and cytoplasm of Sertoli cells. Moreover, during testicular regression and using light microscopy, some elongated spermatids were seen in basal position next to the Sertoli cell nucleus. This Sertoli phagocytic activity was higher in MR and SR phases. TEM confirmed this to be the result of the phagocytic activity of Sertoli cells. In conclusion, during testicular regression in Syrian hamster due to short photoperiod, when germ cells are known to be lost through apoptosis, there is morphological evidences that Sertoli cells are also lost through apoptosis, while some elongated spermatids are phagocytized and eliminated by the Sertoli cells. |
Author | Ferrer, Concepción Madrid, Juan Francisco Beltrán-Frutos, Esther Pastor, Luis Miguel Sáez, Francisco José Seco-Rovira, Vicente |
Author_xml | – sequence: 1 givenname: Vicente surname: Seco-Rovira fullname: Seco-Rovira, Vicente organization: Department of Cell Biology and Histology, Medical School, Instituto Murciano de Investigación Biosanitaria, Regional Campus of International Excellence “Campus Mare Nostrum,” University of Murcia, Murcia, Spain – sequence: 2 givenname: Esther surname: Beltrán-Frutos fullname: Beltrán-Frutos, Esther organization: Department of Cell Biology and Histology, Medical School, Instituto Murciano de Investigación Biosanitaria, Regional Campus of International Excellence “Campus Mare Nostrum,” University of Murcia, Murcia, Spain – sequence: 3 givenname: Concepción surname: Ferrer fullname: Ferrer, Concepción organization: Department of Cell Biology and Histology, Medical School, Instituto Murciano de Investigación Biosanitaria, Regional Campus of International Excellence “Campus Mare Nostrum,” University of Murcia, Murcia, Spain – sequence: 4 givenname: Francisco José surname: Sáez fullname: Sáez, Francisco José organization: Department of Cell Biology and Histology Unidad de Formación e Investigación 11/44, School of Medicine and Dentistry, University of the Basque Country Universidad del País Vasco/Euskal Herrico Unibertsitatea, Leioa, Spain – sequence: 5 givenname: Juan Francisco surname: Madrid fullname: Madrid, Juan Francisco organization: Department of Cell Biology and Histology, Medical School, Instituto Murciano de Investigación Biosanitaria, Regional Campus of International Excellence “Campus Mare Nostrum,” University of Murcia, Murcia, Spain – sequence: 6 givenname: Luis Miguel surname: Pastor fullname: Pastor, Luis Miguel organization: Department of Cell Biology and Histology, Medical School, Instituto Murciano de Investigación Biosanitaria, Regional Campus of International Excellence “Campus Mare Nostrum,” University of Murcia, Murcia, Spain |
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CitedBy_id | crossref_primary_10_1071_RD17409 crossref_primary_10_1093_biolre_ioz198 crossref_primary_10_1093_dnares_dsw057 crossref_primary_10_1002_ece3_2193 crossref_primary_10_1016_j_vetimm_2023_110558 crossref_primary_10_3390_ani12131605 crossref_primary_10_1177_0748730415618297 crossref_primary_10_1007_s13364_015_0224_2 crossref_primary_10_1111_and_13148 crossref_primary_10_1002_ar_25369 crossref_primary_10_1016_j_tice_2020_101484 crossref_primary_10_1111_ahe_13017 crossref_primary_10_1111_rda_13201 crossref_primary_10_1111_andr_12037 crossref_primary_10_1002_jcp_29998 crossref_primary_10_1371_journal_pone_0204851 crossref_primary_10_1159_000439039 |
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Title | The Death of Sertoli Cells and the Capacity to Phagocytize Elongated Spermatids During Testicular Regression due to Short Photoperiod in Syrian Hamster (Mesocricetus auratus)1 |
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