Morphogenesis of bullet-shaped rabies virus particles requires a functional interplay between the viral matrix protein and ESCRT-I component TSG101

• Published in: bioRxiv
• Main Authors: Itakura, Yukari, Tabata, Koshiro, Saito, Takeshi, Intaruck, Kittiya, Kawaguchi, Nijiho, Kishimoto, Mai, Torii, Shiho, Kobayashi, Shintaro, Ito, Naoto, Harada, Michiko, Inoue, Satoshi, Maeda, Ken, Takada, Ayato, Hall, William W., Orba, Yasuko, Sawa, Hirofumi, Sasaki, Michihito
• Format: Paper
• Language: English; Japanese
• Published: Cold Spring Harbor Laboratory 16.12.2022
• Edition: 1.1
• Subjects: Microbiology

Viral protein assembly and virion budding are tightly regulated to enable the proper formation of progeny virions. At this late stage in the virus life cycle, some enveloped viruses take advantage of the host ESCRT (endosomal sorting complex required for transport) machinery, which contributes to th...