Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor

• Published in: bioRxiv
• Main Authors: Jaiswal, Alok, Prson Gautam, Pietila, Elina Amanda, Timonen, Sanna, Nordstrom, Nora, Tanoli, Ziaurrehman, Sipari, Nina, Lehti, Kaisa, Wennerberg, Krister, Aittokallio, Tero
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 02.02.2020; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Breast cancer; Cancer; Cancer Biology; Cell culture; Laboratories; Molecular modelling; PTEN protein; Ribonucleic acid; RNA; Tumor cell lines; Tumor suppressor genes

A caveat of cancer cell line models is that their molecular and functional profiling is subject to laboratory-specific experimental practices and data analysis protocols. The current challenge is how to make an integrated use of omics profiles of cancer cell lines for reliable discoveries. Here, we...