Hypogonadal Mouse, a Model to Study the Effects of the Endogenous Lack of Gonadotropins on Apoptosis1

• Published in: Biology of reproduction Vol. 78; no. 1; pp. 77 - 90
• Main Authors: Chausiaux, Oriane E, Abel, Margaret H, Baxter, Fiona O, Khaled, Walid T, Ellis, Peter J. I, Charlton, Harry M, Affara, Nabeel A
• Format: Journal Article
• Language: English
• Published: Society for the Study of Reproduction, Inc 01.01.2008
• Subjects: apoptosis; follicle-stimulating hormone; gonadotropin-releasing hormone; Hpg; leutenizing hormone; sertoli cells; testis

Testicular apoptosis is involved in the regulation of germ cell numbers, allowing optimal sperm production. Apoptosis has been described to occur in response to the absence of hormonal stimulation of the testis. Here we investigate the effect of the physiological lack of gonadotropins from birth usi...