POS0154 EARLY AND ESTABLISHED RHEUMATOID ARTHRITIS PATIENTS EXHIBIT DISTINCTIVE CIRCULATING INFLAMMATORY SIGNATURES ASSOCIATED WITH RELEVANT BIOLOGIC PATHWAYS

• Published in: Annals of the rheumatic diseases Vol. 83; no. Suppl 1; pp. 298 - 299
• Main Authors: Perez-Sanchez, C., Vellón-García, B., Llamas-Urbano, A., Sanchez-Pareja, I., Muñoz-Barrera, L., Hanaee, Y., Cerdó, T., Merlo-Ruiz, C., Arias-de la Rosa, I., Ruiz-Vilchez, D., Abalos-Aguilera, M. D. C., Ladehesa-Pineda, M. L., Aranda-Valera, C., Rojas-Giménez, M., Calvo-Gutiérrez, J., Collantes-Estevez, E., Barbarroja, N., López-Medina, C., Ortega-Castro, R., Escudero-Contreras, A., Lopez-Pedrera, C.
• Format: Journal Article
• Language: English
• Published: Kidlington BMJ Publishing Group Ltd and European League Against Rheumatism 01.06.2024; Elsevier B.V; Elsevier Limited
• Subjects: Adaptive immunity; Biomarkers; CD40 antigen; Cell differentiation; Chemotaxis; CXCL10 protein; Fibroblast growth factor 23; FLT3L protein; Gene set enrichment analysis; Genetics; Glial cell line-derived neurotrophic factor; Inflammatory diseases; Leukocyte migration; Leukocytes (neutrophilic); Lymphocytes T; Macrophage colony-stimulating factor; Macrophages; Molecular modelling; Nerve growth factor; Oligonucleotides; omics; Pathophysiology; Phenotypes; Prognostic factors; Proteins; Proteomes; Proteomics; Rheumatoid arthritis; Scientific Abstracts; Signatures; Biomarkers; Genetics; omics; Prognostic factors

Background:Rheumatoid arthritis (RA) is a complex chronic inflammatory disease with high heterogeneity. Characterizing the molecular mechanisms linked to different phenotypes might open new opportunities for the development of personalized therapeutic approaches.Objectives:1-To characterize the circ...